Innovation is key to succeed in the new normal. This is the simple message of the recent Vector client survey 2021. Yet, innovation must be balanced with the ongoing market pressure for competitiveness in terms of cost, quality, and competences. Vector has summarized in this white paper best practices from Vector Forum 2021 and from our recent projects. Hands-on industry case studies from Mercedes-Benz, Porsche, Siemens Healthineers, Volkswagen, ZF and Vector practically show across disciplines how to innovate with software.